Once one knows that singularities occur, one naturally wonders what the singularities are like. For minimal varieties the first answer, already known to Federer-Fleming in 1959, is that they weakly resemble cones. For mean curvature flow, by the combined work of Huisken, Ilmanen, and White, singularities weakly resemble shrinkers.   Unfortunately, the simple proofs leave open the possibility that a minimal variety or a mean curvature flow looked at under a microscope will resemble one blowup, but under higher magnification, it might (as far as anyone knows) resemble a completely different blowup. Whether this ever happens is perhaps the most fundamental question about singularities.  It is the proof of this long standing open question that we discuss for mean curvature flow at all generic singularities and for mean convex mean curvature flow at all singularities. This is joint work with Bill Minicozzi.